6

Results

AChE activity in the striatum brain region. The AChE activity

was significantly increased (p<0.001) after 4 and 14 days of

exposure (Fig. 1). After 60

days

of

aluminium

exposure,

the

enzyme

activity

compared

to

control

group

was

significantly

decreased (p<0.001). Increase in enzyme activity after 4 days of

exposure (110%) declined with increase in duration of exposure

to 14 days (61%) and 60 days (-67%).

DISCUSSION

activity in the striatum brain region. Studies have shown that

aluminium is able to produce biochemical changes in the brain at

shorter duration of exposure. Gulya et al., [7] have observed

increase in AChE activity in rats exposed to aluminium after 15

days. However, the increase in enzyme activity reported were not

statistically

significant.

The

results

of

the

present

study

reveal

a

significant

increase

in

AChE

activity

at

shorter

duration (4 and 14 days) of exposure. Earlier reports have shown

increase

in

AChE

activity

on

aluminium

exposure

in

dorsal

thoracic region [17], frontal cortex

[20]

of

rabbits

and

in