For whatever reason, even if my Macbook Pro computer booted with more than 10 GB disk space available, after working on it and having it powered on constantly for a day or two, its disk space very often will fall dramatically and sometimes even almost fill up with nominally something like 200 MB left. And it often causes issues:
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Having to "manually" kill applications that are no longer responsive using Activity Monitor.
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Some applications not properly exiting and saving status and metadata. For example, Eclipse workspace data, backup files in Emacs, and currently opened tabs in Google Chrome.
I made a Bash script to check and warn about low disk space and have it run periodically as a cron job.